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叢書名：中國科學院教材建設專家委員會規(guī)劃教材醫(yī)學英文原版改編雙語教材
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- 作者：（美）羅伯特·韋弗著；藥立波，卜友泉改編
- 出版時間：2020/1/1
- ISBN：9787030629548
- 出 版 社：科學出版社
本套英文改編版教材是我社組織國內一流的院士、學者，以國際著名出版公司美國McGraw-HillCo.優(yōu)秀醫(yī)學教材為基礎，以我國教育部頒布的教學大綱為依據為來華留學生量身制作的全英文醫(yī)學授課教材。本套教材改編時充分考慮了學科發(fā)展及國內外醫(yī)學教育的現狀，結合國內醫(yī)學教育和來華留學生來源國的教學需求。教材在注重課程體系完整性的同時，延續(xù)了學科內容的系統(tǒng)性和連貫性。本書由科學出版社和美國McGraw-HillCo.合作出版。未經出版者預先書面許可，不得以任何方式復制或抄襲本書的任何內容；否則我們將視為違反著作權法，將給予法律追究。
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CONTENTS
CHAPTER 1 INTRODUCTION 1
SECTION 1 A BRIEF HISTORY 1
SECTION 2 MOLECULAR BIOLOGY PROMOTE MEDICINE TO THE MOLECULAR LEVEL 11
CHAPTER 2 THE MOLECULAR NATURE OF GENES 16
SECTION 1 THE NATURE OF GENETIC MATERIAL 16
SECTION 2 STRUCTURE OF NUCLEIC ACIDS 21
SECTION 3 NUCLEOSOME AND CHROMATIN ASSEMBLY 27
SECTION 4 PHYSICAL CHEMISTRY OF NUCLEIC ACIDS 35
CHAPTER 3 NATURE AND FUNCTION OF GENES 42
SECTION 1 THE NATURE OF GENES 42
SECTION 2 PROTEIN STRUCTURE AND FUNCTION 43
SECTION 3 OVERVIEW OF GENE EXPRESSION 49
SECTION 4 REPLICATION 57
SECTION 5 MUTATIONS 58
CHAPTER 4 DNA REPLICATION OF PROKARYOTES 62
SECTION 1 GENERAL FEATURES OF PROKARYOTIC DNA REPLICATION 62
SECTION 2 ENZYMOLOGY OF PROKARYOTIC DNA REPLICATION 69
SECTION 3 DETAILED PROCEDURES OF PROKARYOTIC DNA REPLICATION 79
CHAPTER 5 DNA REPLICATION OF EUKARYOTES 92
SECTION 1 FEATURES OF EUKARYOTIC DNA REPLICATION SYSTEM 92
SECTION 2 DETAILED PROCEDURES OF EUKARYOTIC DNA REPLICATION 103
SECTION 3 TELOMERES AND CANCER 109
CHAPTER 6 DNA DAMAGE AND REPAIR 111
SECTION 1 POLYMORPHISM AND MUTATION OF GENETIC MATERIALS 111
SECTION 2 DNA DAMAGE 112
SECTION 3 DNA REPAIR 115
SECTION 4 OUTCOME OF FAILURE TO REPAIR THE DAMAGED DNA 125
CHAPTER 7 TRANSCRIPTION IN PROKARYOTES 130
SECTION 1 COMPONENTS OF THE PROKARYOTIC TRANSCRIPTION SYSTEM 130
SECTION 2 PROCESS OF THE PROKARYOTIC TRANSCRIPTION 133
CHAPTER 8 REGULATION OF PROKARYOTIC TRANSCRIPTION 142
SECTION 1 GENERAL CONSIDERATIONS ON PROTEIN–DNA INTERACTION 142
SECTION 2 OPERONS: FINE CONTROL OF BACTERIAL TRANSCRIPTION 143
CHAPTER 9 TRANSCRIPTION IN EUKARYOTES 164
SECTION 1 THE EUKARYOTIC TRANSCRIPTION SYSTEM 164
SECTION 2 PROCESS OF THE EUKARYOTIC TRANSCRIPTION 179
CHAPTER 10 REGULATION OF TRANSCRIPTION IN EUKARYOTES 193
SECTION 1 TRANSCRIPTIONAL ACTIVATORS: DEFINITION, CATEGORIES AND MECHANISMS 193
SECTION 2 TRANSCRIPTIONAL REPRESSORS 212
SECTION 3 CHROMATIN REMODELING AND TRANSCRIPTION 213
SECTION 4 REGULATION OF TRANSCRIPTION FACTORS 223
SECTION 5 TRANSCRIPTIONAL COACTIVATORS AND COREPRESSORS 224
SECTION 6 SIGNALING PATHWAYS THAT REGULATE TRANSCRIPTION 230
CHAPTER 11 POST-TRANSCRIPTIONAL EVENTS AND REGULATION 238
SECTION 1 RNA SPLICING 238
SECTION 2 CAPPING AND POLYADENYLATION 250
SECTION 3 OTHER POST-TRANSCRIPTIONAL MECHANISMS OF MRNA REGULATION 260
SECTION 4 PROCESSING EVENTS OF OTHER RNAS 269
CHAPTER 12 TRANSLATION 276
SECTION 1 THE CELLULAR APARATUS FOR TRANSLATION 276
SECTION 2 INITIATION OF TRANSLATION 291
SECTION 3 ELONGATION AND TERMINATION OF TRANSLATION 306
CHAPTER 13 POST-TRANSLATIONAL EVENTS 323
SECTION 1 POST-TRANSLATIONAL PROCESSING AND PROTEIN TRAFFICKING 323
SECTION 2 SITE-SPECIFIC MODIFICATION OF PROTEINS 329
SECTION 3 PROTEIN DEGRADATION 336
CHAPTER 14 DNA RECOMBINATION, TRANSPOSITION & EDITING 341
SECTION 1 THE HOMOLOGOUS RECOMBINATION 342
SECTION 2 TRANSPOSITION 348
SECTION 3 GENE EDITING 358
CHAPTER 15 ONCOGENES AND TUMOR SUPPRESSOR GENES 362
SECTION 1 ONCOGENES 362
SECTION 2 TUMOR SUPPRESSOR GENES 372
SECTION 3 COLLABORATIONS OF ONCOGENES AND TUMOR-SUPPRESSOR GENES IN TUMORIGENESIS 381
CHAPTER 16 MOLECULAR CLONING METHODS 384
SECTION 1 GENE CLONING 384
SECTION 2 THE POLYMERASE CHAIN REACTION 396
SECTION 3 EXPRESSING CLONED GENES 398
CHAPTER 17 METHODS FOR STUDYING GENE FUNCTION 403
SECTION 1 MOLECULAR SEPARATIONS 403
SECTION 2 MOLECULAR TOOLS FOR IDENTIFYING GENES 408
SECTION 3 ASSAYING GENE AND GENE PRODUCT INTERACTIONS 422
SECTION 4 ANALYZING GENE FUNCTION IN THE ORGANISM 429
CHAPTER 18 IDENTIFICATION OF DISEASE-RELATED GENES 434
SECTION 1 A ROUTE MAP FOR IDENTIFYING DISEASE GENES 434
SECTION 2 CHROMOSOMAL POSITIONAL CLONING OF DISEASE GENES 434
SECTION 3 CLONING DISEASE GENES INDEPENDENTLY OF THEIR CHROMOSOMAL POSITION 443
SECTION 4 MODELS FOR CLONING DISEASE-RELATED GENES 446
SECTION 5 FUNCTIONAL VALIDATION OF DISEASE GENES 446
CHAPTER 19 GENE DIAGNOSIS 448
SECTION 1 THE CONCEPT AND CHARACTERISTICS OF GENE DIAGNOSIS 448
SECTION 2 THE BASIC TECHNIQUES IN GENE DIAGNOSIS 449
SECTION 3 THE MEDICAL APPLICATION OF GENE DIAGNOSIS 454
CHAPTER 20 GENE THERAPY 459
SECTION 1 STRATEGIES OF GENE THERAPY 459
SECTION 2 PROCEDURES FOR GENE THERAPY 460
SECTION 3 CLINICAL PRACTICE OF GENE THERAPY 477
CHAPTER 21 GENOMICS AND POST-GENOMICS 484
SECTION 1 TECHNIQUES IN GENOMIC SEQUENCING 484
SECTION 2 STUDYING AND COMPARING GENOMIC SEQUENCES 491
SECTION 3 TRANSCRIPTOMICS 497
SECTION 4 PROTEOMICS 503
SECTION 5 OTHER MOLECULAR OMICS STUDY 511
SECTION 6 BIOINFORMATICS 512
INDEX 517
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